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No adjustments were made to address secondary hypotheses.
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After single oral-dose administration, the maximum observed plasma concentration Cmax of tadalafil is achieved between 30 minutes and 6 hours median time of 2 hours.
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A 10 mg dose of REVATIO Injection is predicted to provide a pharmacological effect of sildenafil and its N-desmethyl metabolite equivalent to that of a 20 mg oral dose.
Overview Key points from the evidence Tadalafil is a reversible phosphodiesterase type 5 inhibitor available as an oral tablet in various strengths.
Acquisition, analysis, or interpretation of data: Pisansky, Pugh, Greenberg, Pervez, Reed, Rosenthal, Mowat, Raben, Buyyounouski, Kachnic, Bruner.
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However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk.
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After 24 hours, the administration of a nitrate may be considered, but once again, appropriate caution with careful monitoring of initial dosages must be used.
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PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis.
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This is an area of particular concern for the patient with congestive heart failure who has a borderline low blood volume and a low blood pressure status as well as for the patient who is following a complicated, multidrug, antihypertensive therapy regimen.
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In order for sildenafil to be effective, sexual stimulation is required.
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Sildenafil should be used in caution with: People with heart or circulation problems People with any deformities in the penis e.
Treatment with tadalafil was well tolerated, with the majority of events being mild or moderate and transient.
It is hypothesized that sildenafil decreases LES, prolongs swallow-induced relaxation, and diminishes the amplitude of peristaltic pressure waves in smooth muscle of the esophagus.
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PAH is high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tirednessSerious side effects have been reported with tadalafil.
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All patients were evaluated 6 weeks after the beginning of the study and the side effects were assessed as well.
The partners of 42 men assigned tadalafil and 40 assigned placebo completed the baseline Sexual Adjustment Questionnaire for partners.
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