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Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells.
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All doses of tadalafil were generally well tolerated, with the most common adverse events being headache, myalgia, and flushing.
In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose monohydrate, and triacetin. canada drug store
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Mortality during the long-term study, by originally assigned dose, is shown in Figure 6:During the study, there were 42 reported deaths, with 37 of these deaths reported prior to a decision to titrate subjects to a lower dosage because of a finding of increased mortality with increasing REVATIO doses.
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Retrieved 10 February 2009.
Originally developed by scientists in Great Britain, it was brought onto the market by Pfizer Inc.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.
Administer REVATIO doses 4—6 hours apart.
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As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:Over time it is possible that Sildenafil citrate can become unsuitable for some people, or they may become unsuitable for it.
Medicines and their possible side effects can affect individual people in different ways.
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The major circulating metabolite results from N-desmethylation of sildenafil, and is, itself, further metabolized.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider.
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Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
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Population pharmacokinetic analysis of data from patients in clinical trials indicated approximately 3-fold the sildenafil clearance when it was co-administered with mild CYP3A inducers.
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Filed Under VIAGRA, History Of ViagraViagra scientific name: sildenafil citrate is a medication originally created by Pfizer Pharmaceuticals as a drug to help men who were suffering from hypertension high blood pressure and angina pectoris a form of ischaemic cardiovascular disease in 1989 in Sandwich, England as compound UK-92,480.
Food and Drug Administration found that tadalafil along with other PDE5 inhibitors was associated with vision impairment related to NAION nonarteritic anterior ischemic optic neuropathy in certain patients taking these drugs in the post-marketing outside of clinical trials setting.
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An agency of the European Union Search document library This is a summary of the European public assessment report EPAR for sildenafil.
Sildenafil metabolism is principally mediated by the CYP3A major route and CYP2C9 minor route cytochrome P450 isoforms.
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It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these.
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Cytochrome P450 3A5 Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Components Name UniProt ID Details Cytochrome P450 3A5 P20815 Details References: Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil.
AbsorptionTadalafil is readily absorbed after oral administration and the mean maximum observed plasma concentration Cmax is achieved at a median time of 2 hours after dosing.