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Turko et al 1999 Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase type 5 by sildenafil and related compounds.
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Subjects who had failed to respond to bosentan were also excluded.
The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite.
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With respect to patients following complicated multidrug, antihypertensive programs, the randomized studies included a large number of hypertensive patients.
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Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995.
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