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Lyn Frumkin, MD, PhD, is a former employee at ICOS Corporation, the codeveloper with Eli Lilly of tadalafil.
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Role of the Sponsors: The study was approved and sponsored by the National Cancer Institute.
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The small RCTs and the observational study have a number of limitations and the results are difficult to relate to clinical practice.
Summary Table of Clinical Recommendations Previous SectionNext Section A.
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CIALIS is a registered trademark of Eli Lilly and Company.
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Effects of Other Substances on TadalafilTadalafil is principally metabolised by CYP3A4.
Lastly, it is possible that longer follow-up of participants in this trial may reveal a late-appearing benefit to tadalafil.
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Appendix B includes a partial listing of commonly prescribed drugs metabolized via the P450 3A4 pathway.
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The significance level for secondary end points was a 2-sided significance level of 0.
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