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A more recent immunohistochemical study 19 suggested that advanced glycation end products e.
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Adverse events were not significantly different between the naive patients compared with the patients on background bosentan therapy.
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The purpose of the recommendation was to raise awareness of clinical trial results showing a higher risk of mortality in pediatric patients taking a high dose of Revatio when compared to pediatric patients taking a low dose.
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The degradation of cGMP into its inactive form, GMP, is catalyzed by cyclic nucleotide phosphodiesterase enzymes.
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