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A more recent immunohistochemical study 19 suggested that advanced glycation end products e.
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Adverse events were not significantly different between the naive patients compared with the patients on background bosentan therapy.
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It has been studied in thousands of patients and used successfully by millions.
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The clinical trial for sildenafil as a drug for ED started in May 1994.
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The purpose of the recommendation was to raise awareness of clinical trial results showing a higher risk of mortality in pediatric patients taking a high dose of Revatio when compared to pediatric patients taking a low dose.
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The degradation of cGMP into its inactive form, GMP, is catalyzed by cyclic nucleotide phosphodiesterase enzymes.
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Nitric oxide NO in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation vasodilation of the intimal cushions of the helicine arteries.
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